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Related Experiment Videos

Arteriovenous anastomoses' function and Raynaud's phenomenon.

G Nuzzaci1, E Pesciullesi, F Lucarelli

  • 1Institute of Medical Clinic I, University of Florence, Italy.

Angiology
|September 1, 1988
PubMed
Summary

This study developed a method to assess arteriovenous anastomoses (AVA) patency in Raynaud

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Area of Science:

  • Vascular Biology
  • Nuclear Medicine
  • Physiology

Background:

  • Raynaud's phenomenon (RP) involves episodic digital ischemia, potentially linked to altered digital circulation.
  • Arteriovenous anastomoses (AVA) play a crucial role in thermoregulation and digital blood flow.
  • Assessing AVA patency non-invasively is important for understanding RP pathophysiology.

Purpose of the Study:

  • To develop and validate a method for quantifying the patency rate of arteriovenous anastomoses (AVA) in the hand.
  • To investigate the effect of cold and heat stimulation on AVA patency and digital total flow (DTF) in healthy subjects and RP patients.

Main Methods:

  • Intrabrachial artery injection of 99mTc-labeled human albumin microspheres.
  • Quantification of lung radioactivity to determine AVA patency rate (APR).

Related Experiment Videos

  • Measurement of digital total flow (DTF) using strain gauge plethysmography.
  • Comparison of DTF and APR under local heat and cold stimulation.

    • Main Results:

    • Cold stimulation significantly reduced both DTF and APR in 25 out of 26 subjects compared to heat stimulation.
    • Raynaud's phenomenon patients exhibited a statistically significant reduction in DTF (P < 0.001) and APR (P < 0.001) upon cold exposure.
    • The findings suggest a correlation between reduced AVA patency and the ischemic phase of RP.

    Conclusions:

    • The developed method effectively quantifies AVA patency in the hand.
    • Reduced AVA patency is a key feature during the ischemic episodes in Raynaud's phenomenon.
    • This technique offers a valuable tool for studying vascular dysfunction in RP.