Pure infundibular pulmonary stenosis induced by radiation therapy--a case report

A sixty-one-year-old woman developed acquired infundibular pulmonary stenosis eleven years after radiation therapy to the mediastinum. On catheterization, there was a 48 mmHg gradient between the right ventricle and the pulmonary artery. Postmortem examination revealed remarkable narrowing of infundibulum. Histologic examination strongly suggested that muscular hypertrophy of the right ventricular outflow tract had been induced by a high dose of radiation therapy.