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Platelet distribution width in young patients with chronic venous insufficiency
Mustafa Aldemir1, Ahmet Yuksel2, Mehmet Inanir3
1Department of Cardiovascular Surgery, 147003University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Vascular
|July 3, 2021
Summary
Platelet distribution width (PDW) is significantly higher in young patients with chronic venous insufficiency (CVI). This finding suggests PDW may serve as a useful indicator for increased inflammation and thrombotic risk in CVI patients.
Area of Science:
- Hematology
- Vascular Medicine
- Biomarkers
Background:
- Platelet distribution width (PDW) is a parameter reflecting platelet size heterogeneity.
- PDW has been associated with various pathological conditions, including inflammatory and thrombotic states.
- The role of PDW in lower extremity chronic venous insufficiency (CVI) remains underexplored, particularly in younger populations.
Purpose of the Study:
- To investigate the association between PDW and lower extremity CVI in young adults.
- To compare PDW levels with other complete blood count (CBC) parameters in individuals with and without CVI.
- To evaluate the diagnostic potential of PDW for CVI.
Main Methods:
- A prospective clinical study involving 108 participants (72 CVI patients, 36 controls) aged 18-50 years.
- Comparison of CBC parameters, including PDW, between the CVI group and a healthy control group.
- Receiver Operating Characteristic (ROC) curve analysis to assess PDW's predictive value for CVI.
Main Results:
- Median PDW was significantly higher in CVI patients (17.6) compared to controls (16.8) (p < 0.001).
- No significant differences were observed in other CBC parameters between the groups.
- ROC analysis indicated PDW could predict CVI with 76% sensitivity at a threshold of 17 and 81% specificity at 17.5.
Conclusions:
- Elevated PDW may indicate an increased inflammatory response and thrombotic tendency in young CVI patients.
- PDW shows potential as a non-invasive biomarker for identifying CVI.
- Further research is warranted to elucidate the precise role of PDW in CVI pathogenesis.
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