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Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind,

Julio Vallejos1, Rodrigo Zoni2, María Bangher1

  • 1Instituto de Cardiología de Corrientes, Bolivar 1334, Zip code, 3400, Corrientes, Argentina.

BMC Infectious Diseases
|July 3, 2021
PubMed
Abstract

Insights

Ivermectin did not significantly prevent hospitalization in early COVID-19 patients. Those treated with ivermectin required invasive mechanical ventilatory support earlier than the placebo group.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Trials

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, prompted research into repurposed treatments.
  • Investigating ivermectin as a potential intervention for early-stage COVID-19 is crucial.

Purpose of the Study:

  • To evaluate the efficacy of ivermectin in preventing hospitalization among non-hospitalized COVID-19 patients.
  • To assess the safety and other efficacy endpoints of ivermectin treatment.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 501 non-hospitalized COVID-19 patients.
  • Patients received either ivermectin or a placebo for two days, with staggered dosing based on weight.
  • Primary outcome was hospitalization; secondary outcomes included safety and viral clearance.

Main Results:

  • No statistically significant difference in hospitalization rates between the ivermectin (5.6%) and placebo (8.4%) groups (p=0.227).
  • Patients receiving ivermectin showed a trend towards earlier need for invasive mechanical ventilatory support (5.25 days vs. 10 days, p=0.019).
  • No significant differences were observed in secondary outcomes like PCR negativity or safety.

Conclusions:

  • Ivermectin demonstrated no significant benefit in preventing hospitalization for COVID-19.
  • Early use of ivermectin may be associated with an earlier requirement for mechanical ventilation.
  • Further research is needed, considering limitations such as hospitalization event rates and population risk profiles.

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