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Intestinal microbiota and active systemic lupus erythematosus: a systematic review
Juliana Rosa Pires Vieira1, Andréa Toledo de Oliveira Rezende2, Marcos Rassi Fernandes1,3
1Postgraduate Program in Health Sciences, School of Medicine of the Universidade Federal de Goiás (UFG), Goiânia, Brazil.
Advances in Rheumatology (London, England)
|July 3, 2021
Summary
This review found distinct gut bacteria patterns in active Systemic Lupus Erythematosus (SLE). Dysbiosis, or an imbalance in gut microbiota, may play a role in SLE disease activity.
Area of Science:
- Immunology
- Microbiology
- Rheumatology
Background:
- Systemic Lupus Erythematosus (SLE) is a multi-system autoimmune disease primarily affecting young women.
- Its pathogenesis involves complex interactions between the immune system and the gut microbiota.
- Understanding these interactions is crucial for managing SLE activity.
Purpose of the Study:
- To systematically review and assess the relationship between intestinal microbiota and SLE disease activity.
- To identify characteristic gut microbiota patterns in patients with active SLE.
- To highlight differences in microbiota quantity and diversity between active SLE and remission.
Main Methods:
- Systematic review of studies including patients meeting SLICC, ACR, or EULAR classification criteria for SLE.
- Inclusion of studies using SLEDAI to define disease activity or remission.
- Searched Medline, Scopus, and Embase databases from October 2020 to January 2021, including five papers with 288 SLE participants.
Main Results:
- Significant increases in Lactobacillus, Streptococcus, Megasphaera, Fusobacterium, Veillonella, Oribacterium, Odoribacter, Blautia, and Campylobacter genera were observed in active SLE patients.
- Conversely, a decrease in Faecalibacterium and Roseburia genera, along with Ruminococcus gnavus species, was noted in patients with SLE in remission.
- These findings indicate distinct microbiota profiles correlating with SLE disease activity status.
Conclusions:
- The results suggest a potential role for gut dysbiosis in the process of SLE disease activity.
- Specific alterations in the intestinal microbiota may serve as biomarkers for SLE activity.
- Further research into the gut-immune axis in SLE is warranted.
