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Updated: Oct 30, 2025

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity
Published on: February 24, 2017
Role of differentiated embryo-chondrocyte expressed gene 1 (DEC1) in immunity
Ning-Lang Yuan1, Yang Liu2, Di Zhang1
1Department of Pathology, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China; Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang 110122, Liaoning Province, China.
Abstract:
Differentiated embryo-chondrocyte expressed gene 1 (DEC1) belongs to the family of basic helix-loop-helix (bHLH)-type transcription factors. DEC1 is expressed in various mammalian cells, but early studies focused on its roles outside the immune system. In recent years, relevant studies have found that DEC1 plays an important role in the immunotherapy of tumors, the functional regulation of the immune system, and the onset of autoimmune diseases. DEC1 promotes interferon (IFN)-γand granulocyte-macrophage colony-stimulating factor (GM-CSF) secretion through the production of CD4+ T cells, which promotes inflammatory defense responses and autoimmune diseases. Additionally, DEC1 can inhibit the expression of interleukin (IL)-10 to further strengthen the immune response. In this review, we summarized recent advances in our understanding of the roles of DEC1 in animal models and human cells, including regulating immune cell differentiation, controlling cytokine production, and maintaining the balance of pro- and anti-inflammatory signals.
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