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Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
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Time-Series Single-Cell Sequencing Reveals Tumor Clonal Dynamics

    Cancer Discovery
    |July 3, 2021
    PubMed
    Summary

    Cancer clone fitness landscapes were altered by mutations and treatments in laboratory and real-world settings. This research explores how these changes impact cancer evolution and treatment resistance.

    Area of Science:

    • Oncology
    • Evolutionary Biology
    • Genetics

    Background:

    • Understanding cancer evolution is crucial for developing effective therapies.
    • Cancer clones exhibit dynamic fitness landscapes influenced by genetic mutations and therapeutic interventions.

    Purpose of the Study:

    • To investigate the impact of mutations and treatments on the fitness landscape of cancer clones.
    • To analyze how these perturbations influence cancer progression and treatment response.

    Main Methods:

    • Utilized in vitro and in vivo models to simulate cancer clone dynamics.
    • Employed genetic sequencing and fitness assays to assess clone evolution.

    Main Results:

    • Observed significant alterations in cancer clone fitness following mutations and treatments.

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    VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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  • Identified specific mutations and treatment strategies that reshape the cancer fitness landscape.

    • Conclusions:

    • Perturbations in the cancer fitness landscape are key drivers of clonal evolution.
    • Targeting these dynamics may offer novel therapeutic strategies for cancer treatment.