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Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
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Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

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FAM64A is an androgen receptor-regulated feedback tumor promoter in prostate cancer

Yingchen Zhou1,2, Longhua Ou3, Jinming Xu3

  • 1Department of Urology, Peking University Shenzhen Hospital, Institute of Urology, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.

Cell Death & Disease
|July 3, 2021
PubMed

Insights

Family With Sequence Similarity 64 Member A (FAM64A) promotes prostate cancer (PCa) development by increasing cell proliferation and migration. Androgen receptor signaling up-regulates FAM64A, offering a potential new therapeutic target for PCa treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (PCa) often progresses to castration-resistant prostate cancer (CRPC) despite endocrine therapy targeting androgen receptor (AR) signaling.
  • The role of Family With Sequence Similarity 64 Member A (FAM64A) in PCa pathogenesis remains unexplored.

Purpose of the Study:

  • To investigate the function of FAM64A in prostate cancer.
  • To determine the association between FAM64A expression and PCa prognosis and underlying mechanisms.

Main Methods:

  • Utilized TCGA database and immunohistochemistry for FAM64A expression analysis in PCa.
  • Performed in vitro knockdown experiments to assess FAM64A's impact on PCa cell behavior.
  • Investigated the regulatory mechanism of FAM64A by dihydrotestosterone (DHT) and AR binding to the FAM64A promoter.

Main Results:

  • FAM64A is upregulated in PCa and correlates with poor prognosis.
  • FAM64A knockdown inhibits PCa cell proliferation, migration, invasion, and cell cycle progression.
  • DHT upregulates FAM64A via direct AR binding to its promoter, promoting androgen-dependent PCa cell growth.
  • Abnormal FAM64A expression impacts immune and interferon signaling pathways in PCa cells.

Conclusions:

  • FAM64A is upregulated by AR signaling, promoting PCa development.
  • FAM64A's role in PCa progression involves immune and interferon signaling pathways.
  • FAM64A represents a potential therapeutic target for prostate cancer.

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