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Economic evaluation in psychiatric pharmacogenomics: a systematic review
Kariofyllis Karamperis1,2, Maria Koromina1,2, Panagiotis Papantoniou3
1The Golden Helix Foundation, London, UK.
The Pharmacogenomics Journal
|July 3, 2021
Summary
Pharmacogenomic (PGx) testing for psychiatric medications is increasingly cost-effective. This review found most studies support PGx, with many showing genome-guided treatment as cheaper or cost-effective compared to standard care.
Area of Science:
- Pharmacogenomics
- Health Economics
- Psychiatric Pharmacology
Background:
- Pharmacogenomic (PGx) testing guides drug prescription but requires cost-effectiveness for healthcare integration.
- Previous studies assessed the economic value of PGx testing for antidepressants and antipsychotics.
Purpose of the Study:
- To systematically review and update evidence on the cost-effectiveness of PGx testing for psychiatric medications.
- To identify drug-gene associations and PGx panel utility in economic evaluations.
Main Methods:
- Systematic literature review of studies evaluating PGx testing cost-effectiveness.
- Inclusion criteria applied to 1159 initially identified studies, resulting in 18 included evaluations.
- Analysis of cost-effectiveness and cost comparison data from selected studies.
Main Results:
- 16 out of 18 studies (88.89%) favored PGx testing.
- 9 studies (50%) found genome-guided interventions cost-effective.
- 7 studies (38.9%) found interventions less costly than standard treatment, particularly for CYP2D6, CYP2C19, and PGx panels.
Conclusions:
- Growing evidence supports the cost-effectiveness of PGx-guided interventions for psychiatric disorders.
- Further research is needed on economic evaluations, especially concerning study design and cost inputs.
- PGx implementation in psychiatry requires more robust economic data for widespread adoption.
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