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The language profile in multiple system atrophy: an exploratory study.

Sofia Cuoco¹, Marina Picillo¹, Immacolata Carotenuto¹

¹Neuroscience Section, Department of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy.

Journal of Neural Transmission (Vienna, Austria : 1996)

|July 3, 2021

Summary

This summary is machine-generated.

Language impairments are common in Multiple System Atrophy (MSA). The MSA-tailored Screening for Aphasia in NeuroDegeneration (SAND) tool reliably identifies these issues, which correlate with cognitive decline.

Keywords:

Cognition Language Mild cognitive impairment Multiple System Atrophy

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Area of Science:

Neuroscience
Linguistics
Neurology

Background:

Limited evidence exists on the language performance profile in Multiple System Atrophy (MSA).
Characterizing language deficits in MSA can enhance understanding of the disorder and basal ganglia's role in language.
Investigating language in neurodegenerative diseases is crucial for comprehensive patient assessment.

Purpose of the Study:

Evaluate the reliability of the Screening for Aphasia in NeuroDegeneration (SAND) in MSA patients.
Compare linguistic profiles of MSA patients with Parkinson's disease (PD) patients and healthy controls (HC).
Assess the relationship between language impairment, cognitive status, and MSA motor subtypes.

Main Methods:

Enrolled 40 MSA patients, 22 HC, and 17 PD patients.
Utilized an MSA-tailored SAND tool, excluding a poorly accepted writing task.
Administered language tasks including repetition, reading, and semantic association.

Main Results:

The MSA-tailored SAND Global Score demonstrated acceptability, consistency, and reliability for screening language disturbances in MSA.
MSA patients showed worse performance than HC but not PD patients on the SAND score, repetition, reading, and semantic association.
No significant differences in language performance were found between MSA phenotypes, but cognitive decline correlated with poorer language outcomes.

Conclusions:

The MSA-tailored SAND Global Score is a reliable tool for identifying language disturbances in MSA.
Language deficits are a characteristic feature of MSA, regardless of phenotype, and are linked to global cognitive decline.