Estimation of an EORTC QLU-C10 Value Set for Spain Using a Discrete Choice Experiment

Area of Science:

• Health Economics
• Psychometrics
• Patient-Reported Outcomes

Background:

• The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) is a widely used cancer survivorship tool.
• The EORTC QLU-C10D is a preference-based index derived from the EORTC QLQ-C30, suitable for economic evaluations.
• Country-specific value sets are essential for accurate economic evaluations using preference-based measures.

Purpose of the Study:

• To generate a novel, country-specific value set for the EORTC QLU-C10D in Spain.
• To facilitate the use of the EORTC QLQ-C30 in health economic assessments within the Spanish population.

Main Methods:

• An online discrete choice experiment was conducted with a sample of the Spanish general population.
• An attribute-balanced incomplete block design was employed, presenting participants with 960 choice tasks representing 1920 unique health states.
• Data were analyzed using generalized estimating equations and mixed logistic regressions to derive utility values.

Main Results:

• A total of 1010 participants completed the study.
• Dimension decrements generally showed monotonic increases with greater severity, indicating higher disutility.
• Physical functioning and pain dimensions exhibited the largest decrements, while sleep disturbances had the smallest. The worst attainable health state (PITS) was valued at -0.043.

Conclusions:

• This research successfully generated the first Spanish value set for the EORTC QLU-C10D.
• The availability of this value set will enhance the feasibility of cost-utility analyses in Spain.
• This contributes to more accurate health economic assessments using EORTC QLQ-C30 data in the Spanish context.