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Immunohistochemical Marker Expression in Temporal Bone Squamous Cell Carcinoma.

Daisuke Maki1, Kenji Okami, Koji Ebisumoto

  • 1Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. d.maki@tokai.ac.jp.

The Tokai Journal of Experimental and Clinical Medicine
|July 3, 2021
PubMed
Summary

Epidermal growth factor receptor (EGFR) overexpression in temporal bone squamous cell carcinoma (TBSCC) correlates with poorer prognosis. This finding suggests EGFR may serve as a valuable prognostic biomarker for TBSCC patients.

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Area of Science:

  • Oncology
  • Pathology
  • Genomics

Background:

  • The prognostic significance of genomic mutations and protein overexpression in temporal bone squamous cell carcinoma (TBSCC) remains unclear.
  • Investigating biomarkers like EGFR and p53 is crucial for predicting patient outcomes in TBSCC.

Purpose of the Study:

  • To evaluate the overexpression of epidermal growth factor receptor (EGFR) and p53 in TBSCC.
  • To determine if EGFR and p53 overexpression can serve as pathological biomarkers for predicting the clinical course and survival outcomes in TBSCC patients.

Main Methods:

  • Retrospective review of 22 TBSCC cases treated between January 2005 and October 2016.
  • Immunohistochemical staining was used to assess EGFR and p53 overexpression.
  • Correlation analysis between protein overexpression and clinicopathological variables, including survival rates.

Main Results:

  • Epidermal growth factor receptor (EGFR) was overexpressed in 40.9% of TBSCC patients.
  • p53 was also overexpressed in 40.9% of the cases studied.
  • A significantly lower 5-year overall survival rate (55.6%) was observed in EGFR-positive patients compared to EGFR-negative patients (92.3%, p = 0.043).

Conclusions:

  • Overexpression of epidermal growth factor receptor (EGFR) in temporal bone squamous cell carcinoma (TBSCC) is associated with unfavorable prognosis.
  • EGFR may function as a potential prognostic biomarker for TBSCC, aiding in clinical decision-making.