Related Experiment Video

Updated: Oct 30, 2025

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

5.8K

Neighborhood Disadvantage and Early Respiratory Outcomes in Very Preterm Infants with Bronchopulmonary Dysplasia

Juliette Deschamps1, Mohamed Boucekine2, Laurence Fayol1

  • 1Neonatal Unit, University Hospital of La Conception, AP-HM, AMU, Marseille, France.

The Journal of Pediatrics
|July 3, 2021
PubMed

Insights

Neighborhood conditions significantly affect respiratory health in very preterm infants with bronchopulmonary dysplasia (BPD). Disadvantaged areas increase rehospitalization risk, highlighting the need for social context in preterm infant care.

Area of Science:

  • Neonatal care
  • Pediatric respiratory health
  • Social determinants of health

Background:

  • Infants born very preterm with bronchopulmonary dysplasia (BPD) face significant respiratory challenges.
  • Post-discharge respiratory outcomes are critical for this vulnerable population.
  • The influence of socioeconomic factors on these outcomes requires further investigation.

Purpose of the Study:

  • To examine the association between neighborhood socioeconomic conditions and respiratory-related hospital admissions in very preterm infants with BPD during their first year after neonatal discharge.
  • To identify specific risk factors contributing to rehospitalization in this cohort.

Main Methods:

  • A cohort of very preterm infants (gestational age <33 weeks) diagnosed with BPD at 36 weeks postconceptional age was studied.
  • Neighborhood socioeconomic status was assessed using a Socioeconomic Deprivation Index.
  • Poisson regression analysis was employed to determine risk factors for rehospitalization.

Main Results:

  • The study included 423 infants; 51% resided in disadvantaged neighborhoods.
  • Respiratory-related hospital admission rates were higher in disadvantaged areas, with a 3-fold increased risk (adjusted IRR 2.79) in these infants compared to those in affluent areas.
  • Extremely preterm infants from disadvantaged areas experienced particularly high admission rates (up to 30%).

Conclusions:

  • Living in disadvantaged neighborhoods negatively impacts the early respiratory health of very preterm infants with BPD.
  • Social context is a crucial factor that should be integrated into the routine follow-up care for preterm infants.
  • Further research into the mechanisms underlying these disparities is essential for developing effective preventive strategies.
Abstract

Keywords:
breastfeedingbronchiolitisbronchopulmonary dysplasiahealth inequalitiespreterm infantsrespiratory distress syndromesocioeconomic status

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.5K
A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease04:21

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

Published on: August 4, 2021

6.4K

Related Concept Videos

Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
61.5K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
2.2K
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
501
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.0K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
437
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.4K