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0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to

Sainath Raman1,2, Andreas Schibler3,4, Renate Le Marsney3

  • 1Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, 62 Graham Street, South Brisbane, QLD, 4101, Australia. sainath.raman@uq.edu.au.

Trials
|July 4, 2021
PubMed

Insights

This study compared balanced intravenous fluids to normal saline in critically ill children. Balanced solutions may reduce the risk of hyperchloremia, a complication associated with normal saline.

Area of Science:

  • Critical Care Medicine
  • Pediatric Critical Care
  • Intravenous Fluid Therapy

Background:

  • Intravenous fluid therapy is a common intervention for critically ill patients.
  • 0.9% sodium chloride (normal saline) is associated with hyperchloremia and worse outcomes.
  • Evidence on optimal fluid choices in critically ill children is limited.

Purpose of the Study:

  • To evaluate if balanced solutions reduce the incidence of increased serum chloride levels compared to 0.9% sodium chloride in critically ill children.
  • To compare the risk of hyperchloremia associated with normal saline versus balanced solutions in pediatric intensive care.

Main Methods:

  • Single-centre, open-label randomized controlled trial with 1:1:1 assignment.
  • Three groups: 0.9% sodium chloride, Plasma-Lyte 148, and Compound Sodium Lactate.
  • Primary outcome: ≥ 5mmol/L increase in serum chloride within 48 hours; 480 patients enrolled; intention-to-treat analysis.

Main Results:

  • This section is not available in the provided abstract.

Conclusions:

  • This pragmatic study assesses a common intervention in pediatric critical care.
  • It compares normal saline to balanced solutions for intravenous fluid therapy.
  • Exclusions include pediatric patients with cardiac conditions or traumatic brain injury.
Abstract

Keywords:
Balanced solutionsBolusChildCritical careIntravenous fluid therapy

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