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Controlling BMP growth factor bioavailability: The extracellular matrix as multi skilled platform.

Laura-Marie A Zimmermann1, Annkatrin Correns1, Ariane G Furlan2

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Cellular Signalling
|July 4, 2021
PubMed
Summary
This summary is machine-generated.

Bone morphogenetic proteins (BMPs) are crucial signaling molecules. Their function is tightly regulated by the extracellular matrix (ECM), and disruptions in this interaction can lead to connective tissue diseases.

Keywords:
Bone morphogenetic protein (BMP)Connective tissue disorderExtracellular matrix (ECM)FibrillinTGF-β

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Bone morphogenetic proteins (BMPs) are signaling ligands from the TGF-β superfamily.
  • BMPs regulate diverse cellular events, including bone formation.
  • Their function is typically studied in isolation, not within the native cellular microenvironment.

Purpose of the Study:

  • To explore the functional interactions controlling BMP bioavailability.
  • To understand how extracellular matrix (ECM) proteins influence BMP signaling.
  • To review mechanisms by which aberrant BMP signaling contributes to connective tissue diseases.

Main Methods:

  • Literature review focusing on BMP-ECM interactions.
  • Analysis of spatio-temporal regulation of BMP bioavailability.
  • Examination of ECM structural disturbances and their impact on BMP signaling.

Main Results:

  • ECM proteins target, present, and control the release of BMP ligands.
  • Structural ECM disturbances due to mutations disrupt BMP signaling.
  • Aberrant BMP signaling is implicated in connective tissue destruction.

Conclusions:

  • The cellular microenvironment, particularly ECM proteins, is critical for proper BMP function.
  • Dysregulated BMP signaling due to ECM alterations drives connective tissue pathology.
  • Understanding these mechanisms is key for addressing inherited and chronic connective tissue diseases.