Use of Stereoelectroencephalography Beyond Epilepsy: A Systematic Review

Area of Science:

• Neurosurgery
• Neuroscience
• Epileptology

Background:

• Stereoelectroencephalography (sEEG) is a surgical technique increasingly used for studying neural circuits in medication-refractory epilepsy.
• It is also employed in scientific research to investigate neural circuitry related to behavior.

Purpose of the Study:

• To review the investigational and therapeutic applications of sEEG in human subjects.
• To assess the potential of sEEG beyond epilepsy treatment.

Main Methods:

• A systematic literature search was conducted using PRISMA guidelines.
• The PubMed database was queried for studies on sEEG applications in humans.
• Abstracts were independently reviewed by two authors for inclusion criteria.

Main Results:

• The search identified 752 articles, with 8 studies selected for review.
• A total of 122 patients were included across the selected studies.
• Indications for sEEG ranged from schizophrenia to Parkinson disease, with all studies being Level IV evidence.

Conclusions:

• sEEG is a valuable method in epilepsy surgery with potential applications in other neurologic and psychiatric disorders.
• Further research using sEEG could enhance pathophysiologic understanding.
• This could lead to improved neuromodulation therapies for various conditions.