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Interaction between testosterone and obesity on hypertension: A population-based cross-sectional study
Dandan Wei1, Jian Hou1, Xue Liu1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Atherosclerosis
|July 4, 2021
Summary
High serum testosterone levels are linked to lower blood pressure and hypertension risk in men, especially when not obese. Obesity can counteract testosterone's protective effects on blood pressure in both sexes.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Obesity Research
Background:
- Investigating the relationship between serum testosterone, obesity, and hypertension in Chinese rural adults.
- Understanding the complex interplay of hormonal and metabolic factors on blood pressure regulation.
Purpose of the Study:
- To evaluate the effects of serum testosterone and obesity on blood pressure parameters and hypertension.
- To explore the interaction between serum testosterone and obesity in relation to hypertension.
Main Methods:
- Recruited 6199 Chinese rural adults from the Henan Rural Cohort Study.
- Measured serum testosterone using liquid chromatography-tandem mass spectrometry.
- Employed logistic regression, linear regression, and generalized linear models to analyze associations and interactions.
Main Results:
- Higher serum testosterone associated with lower hypertension prevalence in males (OR: 0.69, 95% CI: 0.53, 0.89), particularly in non-obese individuals.
- Increased serum testosterone correlated with decreased systolic blood pressure, diastolic blood pressure, and mean arterial pressure in males.
- Found interactive effects: obesity counteracted testosterone's benefits in males; in females, higher testosterone increased blood pressure with high obesity indicators.
Conclusions:
- Elevated serum testosterone is linked to reduced blood pressure and hypertension in males.
- Obesity significantly modifies the effects of serum testosterone on blood pressure and hypertension prevalence in both genders.
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