Related Experiment Video

Updated: Oct 30, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

8.1K

Steroid-refractory chronic graft-versus-host disease: treatment options and patient management

Daniel Wolff1, Giancarlo Fatobene2,3, Vanderson Rocha2,3

  • 1Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany. daniel.wolff@ukr.de.

Bone Marrow Transplantation
|July 4, 2021
PubMed

Insights

Steroid-refractory chronic graft-versus-host disease (SR-cGVHD) after stem cell transplant has poor outcomes. This review clarifies treatment options for SR-cGVHD, guiding second- and third-line therapy choices.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Chronic graft-versus-host disease (cGVHD) significantly impacts survival and quality of life post-allogeneic hematopoietic stem cell transplantation.
  • Current first-line treatments like corticosteroids are often ineffective, leading to steroid-refractory cGVHD (SR-cGVHD).
  • SR-cGVHD presents a critical unmet need due to unclear resistance mechanisms and lack of established treatment guidelines.

Purpose of the Study:

  • To review existing treatment strategies for cGVHD.
  • To explore the rationale for selecting second- and third-line therapies in SR-cGVHD.
  • To provide a framework for personalized treatment decisions in SR-cGVHD.

Main Methods:

  • Literature review of current cGVHD treatments.
  • Development of theoretical case studies to illustrate treatment decision-making.
  • Analysis of factors influencing second- and third-line therapy selection.

Main Results:

  • Current treatment landscape for cGVHD is presented.
  • Case studies demonstrate individualized approaches to SR-cGVHD management.
  • Rationale for various second- and third-line treatment choices is elucidated.

Conclusions:

  • Personalized treatment strategies are crucial for managing SR-cGVHD.
  • Understanding patient-specific profiles can guide optimal therapeutic sequencing.
  • Further research is needed to establish definitive guidelines for SR-cGVHD.

More Related Videos

Murine Full-thickness Skin Transplantation07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

20.6K
Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR06:06

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR

Published on: May 23, 2019

7.3K

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
295
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
253
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
253
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
599
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
77.6K
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
118