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SFPQ promotes an oncogenic transcriptomic state in melanoma

O Bi1, C A Anene2, J Nsengimana3

  • 1School of Applied Sciences, University of Huddersfield, Huddersfield, UK.

Oncogene
|July 4, 2021
PubMed
Summary

Splicing factor, proline- and glutamine-rich (SFPQ) protein drives melanoma by interacting with oncogenic RNAs. Lowering SFPQ slows cancer growth, migration, and impacts key melanoma-associated genes, suggesting SFPQ as a prognostic biomarker.

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