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Updated: Oct 30, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Protective role of IL-18 in host defenses against group B Streptococcus
G Mancuso1, A Midiri2, C Beninati2
1Department of Human Pathology, University of Messina, Messina, Italy. mancusog@unime.it.
Abstract:
The aim of this study was to investigate the role of IL-18, a member of the IL-1 family, in group B Streptococcus (GBS) infection. Both in a neonatal and adult model of GBS infection, IL-18-deficient animals were significantly more susceptible to infection than WT animals. The lack of IL18 was associated with a marked reduction in IFN-γ-levels after bacterial stimulation but did not play a significant role in the recruitment of PMN to sites of GBS infection. Collectively, our data document a fundamental function of IL-18 signaling in boosting the host immune responses against GBS infection.
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