Musicogenic reflex seizure with positive antiglutamic decarboxylase antibody: A case report

The association of musicogenic epilepsy (ME) with antibodies against glutamic decarboxylase (GAD) supports autoimmune workups for these patients. No appropriate treatment has been established for ME; therefore, immunotherapy should be considered for patients who become drug-resistant. The connection between neurological manifestations and antibodies against GAD, a rate-limiting enzyme that helps create the inhibitory neurotransmitter gamma-aminobutyric acid, has been well established. Furthermore, a strong correlation has been found between ME and the temporal lobe. However, its connection with anti-GAD antibodies is still unclear. This paper reports on a 50-year-old right-handed female who has had ME symptoms for 14 years and been found to be anti-GAD antibody-positive. Therefore, we will elaborate on the relation between ME and anti-GAD antibodies.