Related Experiment Video
Updated: Oct 30, 2025
07:15
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
2.7K
Left Ventricular Dysfunction Caused by IgG4-related Small Intramural Coronary Periarteritis
Tasuku Hada1, Masashi Amano1, Yuki Irie1
1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan.
Internal Medicine (Tokyo, Japan)
|July 5, 2021
Summary
Immunoglobulin G4-related disease (IgG4-RD) typically affects multiple organs but rarely involves the heart. This case highlights IgG4-related disease causing left ventricular dysfunction due to cardiac infiltration.
Area of Science:
- Cardiology
- Immunology
- Rheumatology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a multisystem fibroinflammatory condition.
- While IgG4-RD can affect various organs, myocardial involvement is exceptionally rare.
Observation:
- A patient presented with left ventricular dysfunction.
- Cardiac imaging and biopsy revealed findings consistent with IgG4-RD infiltration of the myocardium.
Findings:
- The patient's left ventricular dysfunction was attributed to cardiac IgG4-related disease.
- Histopathological examination confirmed IgG4-positive plasma cell infiltration in the heart tissue.
Implications:
- This case expands the known spectrum of IgG4-RD manifestations.
- Highlights the importance of considering IgG4-RD in unexplained cardiac dysfunction.
- Suggests potential for cardiac involvement in systemic autoimmune disorders.
More Related Videos
Related Concept Videos
01:21Myocarditis I: Introduction
109
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
109
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
135
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
135
01:23Rheumatic Heart Disease I: Introduction
137
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
137
01:14Myocarditis III: Medical Management
41
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
41
01:22Pericarditis I: Introduction
71
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
71
01:27Myocarditis II: Clinical Features and Diagnostic Tests
67
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
67