Related Experiment Video
Updated: Oct 30, 2025
10:12
Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
Published on: March 23, 2022
9.0K
Advancing lung organoids for COVID-19 research
Jelte van der Vaart1, Mart M Lamers2, Bart L Haagmans2
1Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands.
Disease Models & Mechanisms
|July 5, 2021
Summary
Lung organoids offer a realistic model for studying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and developing treatments. This research highlights their value for understanding viral pathogenesis and preparing for future pandemics.
Area of Science:
- Virology
- Cell Biology
- Pathogenesis
Background:
- The COVID-19 pandemic highlighted the urgent need for effective antiviral treatments.
- Inaccurate cellular models can hinder research progress and resource allocation.
- Developing representative model systems is crucial for studying emerging viral threats.
Purpose of the Study:
- To evaluate the utility of organoid model systems for studying SARS-CoV-2.
- To emphasize the importance of lung organoids in understanding viral pathogenesis.
- To establish a foundation for studying future pandemic viruses and therapeutic development.
Main Methods:
- Collaborative efforts between cell biologists and virologists.
- Development of organoid model systems that mimic the in vivo cellular environment.
- Utilizing lung organoids to investigate SARS-CoV-2.
Main Results:
- Organoid model systems have been rapidly developed.
- Lung organoids provide a representative model for SARS-CoV-2 research.
- These models enhance understanding of SARS-CoV-2 pathogenesis.
Conclusions:
- Lung organoids significantly advance the study of SARS-CoV-2.
- Organoid models are vital for understanding viral diseases.
- This approach provides a framework for developing treatments against future pandemic viruses.
