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Feasibility and Safety of Continuous Glucose Monitoring in Infants at Risk of Hypoglycemia in a Rooming-in Setting

Kryštof Tabery1, Ladislava Doležalová2, Miloš Černý3

  • 1Department of Neonatology, Motol University Hospital, Second Faculty of Medicine, Charles University, Prague, Czech Republic.

Fetal and Pediatric Pathology
|July 5, 2021
PubMed

Insights

Continuous glucose monitoring (CGM) in newborns is safe for clinical and developmental outcomes in a rooming-in setting. This pilot study found no adverse neurodevelopmental effects in infants monitored with real-time CGM.

Area of Science:

  • Neonatal Medicine
  • Medical Technology
  • Pediatric Neurology

Background:

  • Current neonatal hypoglycemia screening relies on intermittent blood sampling.
  • Continuous glucose monitoring (CGM) offers improved glucose control and patient comfort.
  • Previous CGM use in neonates was limited to intensive care or blinded settings.

Purpose of the Study:

  • To evaluate the safety and feasibility of real-time continuous glucose monitoring (CGM) in a rooming-in setting for newborns.
  • To assess the clinical and neurodevelopmental outcomes of infants monitored with CGM from birth.

Main Methods:

  • CGM devices were applied within the first two hours of life.
  • Low glucose readings were confirmed with blood glucose measurements to prevent overtreatment.
  • Neurodevelopmental evaluations were conducted at 24 months using Bayley scales.

Main Results:

  • 44 infants were enrolled in the pilot study.
  • CGM identified three infants with verified hypoglycemia.
  • No infants demonstrated neurodevelopmental deficits below 2 standard deviations on Bayley scales, with median scores in cognitive, language, and motor domains.

Conclusions:

  • Real-time CGM in a rooming-in environment is clinically safe and does not negatively impact neurodevelopmental outcomes.
  • Further randomized trials are necessary to confirm superiority in long-term outcomes.

Keywords:
Neonatal hypoglycemiacontinuous glucose monitoringneurodevelopmentscreening

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