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Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors
T Spasokukotskaja1, G Spyrou, M Staub
1Institute of Biochemistry I., Semmelweis University Medical School, Budapest, Hungary.
Biochemical and Biophysical Research Communications
|September 15, 1988
Abstract:
Deoxycytidine metabolism was investigated in light density human tonsillar lymphocytes using 5-3H-deoxycytidine as extracellular precursor. A significant portion of the deoxycytidine (more than 50% of ethanol soluble pool) was found to incorporate into dCDP-choline and dCDP-ethanolamine beside the well-known pathway i.e. incorporation into DNA in form of dCMP and dTMP. Hydroxyurea increased the labeling of the deoxyliponucleotides from 5-3H-deoxycytidine in spite of its inhibition of DNA synthesis.