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Updated: Aug 12, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Assignment of the non-exchangeable proton resonances and solution conformation of the
1Department of Chemistry, University College, University of New South Wales, Australian Defence Force Academy, Campbell, ACT.
Abstract:
The non-exchangeable base and sugar protons of the dodecanucleotide d(CAATCCGGATTG) have been assigned by the combined use of one and two-dimensional NMR spectroscopy. The sequential assignments of the base and sugar protons have been obtained using two dimensional nuclear Overhauser effect and homonuclear shift correlated spectra. By analysis of the nuclear Overhauser effect data it was determined that the dodecanucleotide assumes a right handed B-type helix in the aqueous medium used in this study.
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