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Updated: Aug 11, 2026
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Allogeneic Bone Application in Association with Platelet-Rich Plasma for Alveolar Bone Grafting of Cleft Palate
Cimara Fortes Ferreira1, João Luiz Carlini2, Ricardo de Souza Magini3
1Associate Professor of the Department of Periodontology - University of Tennessee Health Sciences College of Dentistry, Memphis, TN, USA.
Aim:
The aim of this study is to compare allogeneic bone grafts associated with platelet-rich plasma (ALBGs-PRP) to autogenous bone grafts (ATBGs) for alveolar reconstructions in patients with cleft lip and palate (CLP).
Materials And Methods:
The Maxillofacial Surgery Service of the Comprehensive Care Center for CLP (CCCLP) in Curitiba (Paraná, Brazil).
Patients:
Thirty out of 46 patients with 8-12 years of age and pre- or trans-foramen unilateral clefts were operated by the same surgeon. Groups were selected randomly after coin-toss for the first surgery to be ALBG-PRP.
Interventions:
Pre- and post-surgery cleft defect severity was registered by a score system using superimposed digitalized peri-apical radiographs. The hypothesis indicated ABG-PRP to be similar to the ABG was proved.
Results:
There was no statistically significant difference (P < 0.05) in bone augmentation for the ABG-PRP group (79.88%) when compared to the ABG group (79.9%).
Conclusion:
ABG-PRP is indicated as a successful treatment modality to reduce the need for additional donor sites and reduce morbidity and hospital stay.
