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Updated: Oct 30, 2025
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Mendelian randomization analysis identified genes potentially pleiotropically associated with periodontitis
Feng Wang1, Di Liu2, Yong Zhuang3
1Department of Stomatology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Saudi Journal of Biological Sciences
|July 5, 2021
Summary
This study identified genes potentially causing periodontitis using Mendelian randomization. Findings highlight genes like PDCD2, BX093763, and AC104135.3, offering therapeutic targets for periodontitis treatment.
Area of Science:
- Genetics
- Periodontology
- Biostatistics
Background:
- Periodontitis is a complex inflammatory disease with a significant genetic component.
- Understanding the genetic underpinnings of periodontitis is crucial for developing effective treatments.
- Pleiotropic gene associations offer insights into disease mechanisms.
Purpose of the Study:
- To identify genes with pleiotropic or causal associations with periodontitis.
- To prioritize candidate genes for further investigation into periodontitis pathogenesis.
- To discover potential therapeutic targets for periodontitis.
Main Methods:
- Applied the summary data-based Mendelian randomization (SMR) method.
- Integrated genome-wide association study (GWAS) data for periodontitis with expression quantitative trait loci (eQTL) data.
- Performed SMR analysis using CAGE and GTEx eQTL data across European and East Asian ancestries.
Main Results:
- Identified multiple genes associated with periodontitis in both European and East Asian ancestries.
- Top hit in Europeans (CAGE eQTL): PDCD2.
- Top hits in East Asians (CAGE eQTL): BX093763; (GTEx eQTL): AC104135.3.
Conclusions:
- Multiple genes implicated in periodontitis pathogenesis across different ancestries.
- Findings provide crucial insights into periodontitis mechanisms.
- Identified potential therapeutic targets for periodontitis treatment.
Keywords:
Expression quantitative trait lociGO, Gene ontologyGWAS, Genome-wide association studiesHEIDI, Heterogeneity in dependent instrumentsIVs, Instrumental variablesKEGG, Kyoto Encyclopedia of Genes and GenomesLD, Linkage disequilibriumMR, Mendelian randomizationPeriodontitisPleotropic associationSMR, Summary data-based Mendelian randomizationSummary Mendelian randomizationeQTL, expression quantitative trait loci
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