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Mangosteen Hinders Gamma Radiation-Mediated Oxidative Stress and Liver Injury by Down-Regulating TNF-α/NF-κB and

Asmaa A Hassan1, Enas M Moustafa1, Iman Hesham El-Khashab2

  • 1Department of Radiation Biology, National Center for Radiation Research & Technology, (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.

Dose-Response : a Publication of International Hormesis Society
|July 5, 2021
PubMed
Abstract

Insights

Mangosteen extract (MGS) protects against liver damage from ionizing radiation (IR). MGS treatment reduced oxidative stress, inflammation, and cell death, promoting liver health after IR exposure.

Area of Science:

  • Biomedical Science
  • Toxicology
  • Natural Product Research

Background:

  • Ionizing radiation (IR) exposure can cause liver injury, altering protein expression related to inflammation and apoptosis.
  • Radiotherapy and accidental exposure are common scenarios for IR-induced liver damage.
  • Investigating natural compounds for protective effects against IR-induced hepatotoxicity is crucial.

Purpose of the Study:

  • To evaluate the curative potential of Mangosteen (MGS) extract against ionizing radiation (IR)-induced liver damage in Wistar rats.
  • To assess the impact of MGS on oxidative stress, inflammation, and cell proliferation markers in irradiated livers.
  • To elucidate the mechanisms underlying MGS's protective effects against IR-induced hepatotoxicity.

Main Methods:

  • Hepatotoxicity was induced in Wistar rats using a single 6 Gy dose of IR.
  • Mangosteen (MGS) extract (500 mg/kg body weight) was administered orally daily for 30 days post-irradiation.
  • Liver function tests, oxidative stress markers (MDA, SOD, CAT, NO), inflammatory markers (TNF-α, IL-6, CRP), NF-Kappa-B, TGF-β1, and PCNA were analyzed.

Main Results:

  • MGS treatment significantly attenuated IR-induced redox imbalance and liver toxicity.
  • MGS administration ameliorated liver function tests, reduced MDA and NO levels, and restored SOD and CAT activities.
  • MGS inhibited inflammatory markers (TNF-α, IL-6, CRP), downregulated NF-Kappa-B/TGF-β1, and improved PCNA expression, confirmed by histological analysis.

Conclusions:

  • Mangosteen (MGS) extract demonstrates significant protective effects against ionizing radiation (IR)-induced liver injury.
  • MGS ameliorates IR-induced liver damage by minimizing oxidative stress, inflammation, and apoptosis.
  • MGS may serve as a promising supplement for managing irradiation-induced liver injury, potentially through TNF-α/NF-κB/TGF-β1 pathway modulation.
Keywords:
MGSTNF-α/NF- κB/TGF-β1apoptosisionizing radiationliver

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