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Cytogenetics of 12 cases of renal adenocarcinoma
B de Jong1, J W Oosterhuis, V J Idenburg
1Department of Human Genetics, State University, Groningen, The Netherlands.
Cancer Genetics and Cytogenetics
|January 1, 1988
Abstract:
The cytogenetics of 12 cases of renal adenocarcinoma are presented. Clonal abnormalities were found in nine patients. Worth mentioning are abnormalities of the X chromosome (1 X) and the chromosomes #1(3 X), #3(3 X), #7(4 X), #8(4 X), and #14(2 X). From our data and data from the literature it appeared that the chromosomal regions 3p11-p21, 1q21, 14q22, and Xp11 are important for the oncogenesis of renal cell carcinoma as well as increased dosage of chromosome #7 and loss or abnormalities of chromosomes #8 and #14.