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Long-Term Increase in Cholesterol Is Associated With Better Cognitive Function: Evidence From a Longitudinal Study.
Huamin Liu1, Lianwu Zou2, Rui Zhou1
1Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Frontiers in Aging Neuroscience
|July 5, 2021
Summary
A longitudinal increase in non-high-density lipoprotein cholesterol (NHDL-C) may protect cognition, particularly in women and those without cardiovascular disease. This finding suggests cholesterol variation impacts long-term cognitive health.
Area of Science:
- Neurology
- Cardiovascular Science
- Gerontology
Background:
- Visit-to-visit cholesterol variability is linked to cognitive decline.
- Long-term cholesterol trends and their impact on cognition require further investigation.
Purpose of the Study:
- To examine the association between long-term cholesterol level changes and cognitive decline.
- To identify specific cholesterol metrics and demographic factors influencing this relationship.
Main Methods:
- Analysis of 4,915 participants (≥45 years) with baseline normal cognition.
- Categorization into cholesterol change groups (low-low, low-high, high-low, high-high) based on total cholesterol, NHDL-C, LDL-C, and HDL-C after 4 years.
- Cognitive function assessed via episodic memory and mental intactness; binary logistic regression used for analysis.
Main Results:
- Global cognitive decline observed in 19.9% of participants.
- A low-to-high NHDL-C trajectory was associated with significantly lower odds of global cognitive decline (OR 0.50) and memory decline (OR 0.45).
- This protective effect was more pronounced in females and individuals without cardiovascular disease.
Conclusions:
- Longitudinal increases in NHDL-C may offer a protective effect on cognitive function.
- This association is particularly relevant for females and individuals without pre-existing cardiovascular disease.
- Further research into cholesterol dynamics and cognitive health is warranted.
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