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Macrophage Related Chronic Inflammation in Non-Healing Wounds

Meirong Li1,2,3,4, Qian Hou1,2,3, Lingzhi Zhong1,2,3

  • 1Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical College, Beijing, China.

Frontiers in Immunology
|July 5, 2021
PubMed

Insights

Chronic wounds involve persistent inflammation due to macrophage dysfunction. This review explores macrophage roles in healing and non-healing wounds, highlighting therapeutic strategies to restore macrophage function for better chronic wound treatment.

Area of Science:

  • Wound healing research
  • Immunology
  • Cell biology

Background:

  • Chronic wounds are characterized by persistent hyper-inflammation.
  • Macrophage malfunction is a key factor contributing to non-healing wounds.
  • Understanding macrophage heterogeneity is crucial for therapeutic development.

Purpose of the Study:

  • To review macrophage origin, heterogeneity, and function in wound healing.
  • To compare macrophage roles in healing versus non-healing chronic wounds.
  • To discuss therapeutic strategies for restoring macrophage function in chronic wounds.

Main Methods:

  • Literature review of macrophage biology in wound healing.
  • Analysis of factors contributing to macrophage dysregulation.
  • Examination of systemic and topical therapeutic interventions.
  • Highlighting multidimensional analysis integrating high-throughput technologies.

Main Results:

  • Macrophages exhibit diverse origins and functions during wound healing.
  • Dysregulated macrophages contribute to chronic inflammation in non-healing wounds.
  • Various intrinsic and extrinsic factors influence macrophage behavior.
  • Multidimensional analysis reveals macrophage diversity and communication.

Conclusions:

  • Restoring macrophage function is a promising therapeutic avenue for chronic wounds.
  • Targeting macrophage dysregulation can address persistent inflammation.
  • Advanced analytical techniques offer insights into macrophage-mediated wound repair.
Keywords:
agingchronic inflammationchronic wounddiabetesheterogeneitymacrophagemultidimensional analysis

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