Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.2K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.3K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The posteroventral part of the medial amygdala nucleus glutamatergic neurons encodes conspecifics' individual identity in rodents.

Science advances·2026
Same author

TRIM21 Exacerbates Ischemic Brain Injury by Promoting Astrocyte-Mediated Neuroinflammation via K63-Linked Ubiquitination of MDA5.

Research (Washington, D.C.)·2026
Same author

Retraction Note: Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.

Journal of neuroinflammation·2025
Same author

Recurrent Subdural Hematoma: A Case Report of Diagnostic Pitfall of Spontaneous Intracranial Hypotension and Successful Management With Targeted Epidural Blood Patch.

Clinical case reports·2025
Same author

UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Clinical prediction model of invalid recanalization after complete reperfusion after thrombectomy in acute ischemic stroke patients: a large retrospective study.

Journal of neurointerventional surgery·2025

Related Experiment Video

Updated: Oct 30, 2025

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

4.8K

Progress in Mesenchymal Stem Cell Therapy for Ischemic Stroke.

Yinghan Guo1, Yucong Peng1, Hanhai Zeng1

  • 1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Stem Cells International
|July 5, 2021
PubMed
Summary

Mesenchymal stem cell (MSC) therapy shows promise for ischemic stroke (IS) treatment by aiding immune regulation, neuroprotection, and neural repair. MSC-derived extracellular vesicles (EVs) offer enhanced neuroprotection, potentially expanding the therapeutic window for IS.

More Related Videos

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

10.6K
Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

4.6K

Related Experiment Videos

Last Updated: Oct 30, 2025

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

4.8K
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

10.6K
Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

4.6K

Area of Science:

  • Regenerative Medicine
  • Neurology
  • Stem Cell Biology

Background:

  • Ischemic stroke (IS) is a leading cause of disability worldwide, with current treatments offering limited efficacy.
  • Mesenchymal stem cells (MSCs) are emerging as a promising therapeutic strategy for IS due to their multifaceted regenerative capabilities.

Purpose of the Study:

  • To review the current progress and mechanisms of Mesenchymal stem cell (MSC) therapy for ischemic stroke (IS).
  • To explore the therapeutic potential of MSCs and their derivatives, such as extracellular vesicles (EVs), in treating IS.

Main Methods:

  • Review of recent studies on MSC therapy for IS, focusing on mechanisms, delivery routes, and enhancement strategies.
  • Analysis of the role of immune regulation, neuroprotection, angiogenesis, and neural reconstruction in MSC treatment.
  • Evaluation of MSC-derived extracellular vesicles (EVs) as a therapeutic agent.

Main Results:

  • MSCs exert therapeutic effects through immune modulation, neuroprotection, angiogenesis, and neural circuit repair.
  • MSC-derived EVs demonstrate superior neuroprotection compared to MSCs alone.
  • Optimal administration of MSC therapy may occur within 7 days post-stroke, with various delivery routes (intraventricular, intravascular, intranasal, intraperitoneal) being explored.
  • Enhancement techniques like hypoxic preconditioning and gene technology improve MSC homing and survival.

Conclusions:

  • MSC therapy represents a promising strategy for treating ischemic stroke, offering potential for improved patient outcomes.
  • The use of MSC-derived EVs and advanced technologies like gene modification could further enhance therapeutic efficacy for IS.