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Cutaneous pseudolymphoma: A clinicopathological study and immunohistochemical patterns.
Fatemeh Sari Aslani1, Mozhdeh Sepaskhah1, Akbar Safaei2
1Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Caspian Journal of Internal Medicine
|July 5, 2021
Summary
Cutaneous pseudolymphoma (PSL) can mimic lymphoma. This study analyzed 30 PSL cases, finding nodular patterns and B-cell predominance, with no lymphoma suspicion after immunohistochemical staining.
Area of Science:
- Dermatopathology
- Oncology
- Immunohistochemistry
Background:
- Cutaneous pseudolymphoma (PSL) presents diagnostic challenges due to its resemblance to cutaneous lymphoma.
- Accurate differentiation is crucial for appropriate patient management.
Purpose of the Study:
- To evaluate the clinicopathological and immunohistochemical (IHC) features of cutaneous pseudolymphoma (PSL).
- To aid in distinguishing PSL from cutaneous lymphoma.
Main Methods:
- Retrospective analysis of 30 cutaneous PSL cases from 2013-2017.
- Inclusion of clinical data, histopathological features, and IHC findings.
- Statistical analysis of collected data.
Main Results:
- Median age of patients was 47 years, with a 2:1 female to male ratio.
- Lesions predominantly occurred on the head and neck (86.7%).
- Nodular pattern (76.7%) was most common, with B-cell type (36.6%) slightly more prevalent than T-cell type (33.3%) via IHC.
Conclusions:
- Immunohistochemistry confirmed no suspicion of cutaneous lymphoma in any case.
- Histological and IHC findings support nodular and B-cell types as most common in PSL.
- Clinicopathological features align with previous studies, reinforcing diagnostic criteria.
