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Updated: Oct 30, 2025

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

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Comprehensive Analysis of Regulatory Network for LINC00472 in Clear Cell Renal Cell Carcinoma

Shuoze Gao1, Zhiping Wang1

  • 1Institute of Gansu Nephro-Urological Clinical Center, Department of Urology, Institute of Urology, Key Laboratory of Urological Disease of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China.

Journal of Healthcare Engineering
|July 5, 2021
PubMed

Insights

Low expression of Linc00472, a long noncoding RNA, is linked to aggressive clear cell renal cell carcinoma (ccRCC). This finding suggests Linc00472 may be a potential biomarker for ccRCC diagnosis and treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive kidney cancer subtype.
  • Current targeted therapies for ccRCC are not universally effective, necessitating research into novel therapeutic targets.
  • Long noncoding RNAs (LncRNAs) are increasingly recognized for their roles in cancer development and progression.

Purpose of the Study:

  • To investigate the role of Linc00472 in the molecular mechanisms of ccRCC.
  • To explore Linc00472 as a potential diagnostic and therapeutic target for ccRCC.

Main Methods:

  • Analysis of Linc00472 expression levels in ccRCC tissues compared to normal tissues.
  • Correlation analysis between Linc00472 expression and clinical parameters (e.g., Furman grade).
  • Bioinformatic analysis including protein-protein interactions, functional enrichment, and target gene prediction to elucidate molecular pathways.

Main Results:

  • Linc00472 expression is significantly downregulated in ccRCC tissues.
  • Low Linc00472 expression correlates with higher Furman grade and poorer patient prognosis.
  • Linc00472 may function as a competing endogenous RNA (ceRNA) in pathways involving microRNAs (e.g., miR-24-3p, miR-221-3p, miR-17-5p) and target genes like HLA-DPB1, CXCL9, C3aR1, and VEGFR2.

Conclusions:

  • Linc00472 is a potential tumor suppressor in ccRCC.
  • Downregulation of Linc00472 is associated with ccRCC progression and poor outcomes.
  • Linc00472 warrants further investigation as a biomarker for ccRCC diagnosis and a potential therapeutic target.

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