Related Experiment Video

Updated: Oct 30, 2025

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

6.4K

High-sensitivity troponins in dialysis patients: variation and prognostic value

Sunna Snaedal1,2, Peter Bárány1, Sigrún H Lund3

  • 1Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Clinical Kidney Journal
|July 5, 2021
PubMed

Insights

Elevated cardiac troponins (cTns) are common in dialysis patients. Persistently high troponin T levels significantly increase mortality risk, highlighting the need for serial monitoring in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Research

Background:

  • Dialysis patients face high cardiovascular mortality.
  • Elevated cardiac troponins (cTns) are prevalent, even without acute cardiac ischemia.
  • Understanding cTn variability and prognostic value is crucial.

Purpose of the Study:

  • To assess the variation and prognostic significance of high-sensitivity cardiac troponin I (cTnI) and troponin T (cTnT) in prevalent dialysis patients.
  • To evaluate the diagnostic utility of serial cTn measurements in this cohort.

Main Methods:

  • Serum cTnI and cTnT measured every 4 months in 198 hemodialysis (HD) and 78 peritoneal dialysis (PD) patients.
  • Variability assessed using Reference Change Values (RCVs).
  • Survival analyses conducted using competing-risk regression models over a 50-month follow-up.

Main Results:

  • Similar troponin levels observed between HD and PD patients.
  • A high percentage of patients had troponin levels above myocardial infarction decision levels (42% for cTnI, 98% for cTnT).
  • Elevated troponin T, but not cTnI, predicted mortality after adjusting for confounders.

Conclusions:

  • Many dialysis patients without active cardiac events exhibit elevated high-sensitivity cTns.
  • Persistently high troponin T levels were associated with doubled mortality risk.
  • Large intraindividual cTn variation suggests serial measurements and RCVs can enhance diagnostic utility, though further research is needed.
Abstract

Keywords:
dialysishigh-sensitivity troponinssurvivalvariability

More Related Videos

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.2K
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.4K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
460
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
106
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
55
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
159
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
281
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
160