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SARS-CoV-2-related Multisystem Inflammatory Syndrome in Children: A case series

Nawal Al Maskari1, Kholoud Al Mukhaini1, Safiya Al Abrawi1

  • 1Department of Child Health, Royal Hospital, Muscat, Oman.

Sultan Qaboos University Medical Journal
|July 5, 2021
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C), a COVID-19 complication, presents with hyperinflammation. This study reports on six Omani children with MIS-C who fully recovered with supportive care and specific treatments.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Emergence of a novel hyperinflammatory syndrome linked to COVID-19 in children.
  • Multisystem Inflammatory Syndrome in Children (MIS-C) shares features with Kawasaki disease and toxic shock syndrome.

Observation:

  • Six pediatric cases of MIS-C admitted to Omani hospitals (June-July 2020).
  • Presentations varied, including need for pediatric intensive care unit support and appendicitis suspicion.
  • Five patients were younger than the reported median age for MIS-C.

Findings:

  • All six pediatric patients achieved complete recovery.
  • Treatment involved supportive management, intravenous immunoglobulin, steroids.
  • One patient required an interleukin-6 inhibitor (tocilizumab) for refractory symptoms.

Implications:

  • Highlights the occurrence and clinical spectrum of MIS-C in Oman.
  • Demonstrates the effectiveness of current treatment modalities for MIS-C.
  • Suggests potential for MIS-C to affect younger children than previously documented.

Keywords:
COVID-19Case ReportKawasaki DiseaseMultisystem Inflammatory Syndrome in ChildrenOmanSARS-CoV-2Toxic Shock Syndrome

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