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IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Updated: Oct 30, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Acute Stroke Management: Overview and Recent Updates.

Mary Hollist1, Larry Morgan2, Rainier Cabatbat2

  • 11Memorial Healthcare Institute for Neurosciences, Owosso, MI, USA.

Aging and Disease
|July 5, 2021
PubMed
Summary
This summary is machine-generated.

Acute stroke care has advanced significantly, moving towards personalized treatments like mechanical thrombectomy and thrombolytics to preserve brain tissue and improve patient outcomes. Early intervention is crucial for better functional independence after stroke.

Keywords:
Intravenous tissue plasminogen activator (IV tPA)mechanical thrombectomystroketenecteplasethrombolytics

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Emergency Medicine

Background:

  • Stroke is a major cause of death and disability, with limited treatment options prior to the 1990s.
  • Acute stroke management has seen significant progress, particularly for ischemic stroke, yet few patients receive timely treatment.
  • Advances aim to expand treatment eligibility and improve outcomes for both hemorrhagic and ischemic stroke patients.

Purpose of the Study:

  • To review recent advancements in acute ischemic stroke management.
  • To discuss the evolving treatment paradigms, including mechanical thrombectomy and thrombolytics.
  • To highlight the shift towards tissue preservation and individualized patient care.

Main Methods:

  • Review of recent clinical trials and guidelines for acute ischemic stroke.
  • Analysis of endovascular therapy (EVT) and intravenous thrombolysis (IV tPA) efficacy and time windows.
  • Discussion of advanced neuroimaging techniques (CT, MRI) for patient selection.

Main Results:

  • Numerous trials have expanded treatment eligibility for acute stroke.
  • Current management focuses on reperfusion, tissue preservation, and minimizing secondary events.
  • Individualized treatment strategies using multimodal imaging are becoming standard.

Conclusions:

  • Acute stroke management is transitioning from time-window-based to tissue-based approaches.
  • Mechanical thrombectomy and thrombolytics, including tenecteplase, are key components of modern stroke care.
  • Optimizing acute stroke treatment improves functional independence and reduces long-term disability.