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Role of Cell Death in Cellular Processes During Odontogenesis.
John Abramyan1, Poongodi Geetha-Loganathan2, Marie Šulcová3,4
1Department of Natural Sciences, University of Michigan-Dearborn, Dearborn, MI, United States.
Frontiers in Cell and Developmental Biology
|July 5, 2021
Summary
Programmed cell death, or apoptosis, is crucial for tooth development (odontogenesis). This review explores the roles of apoptotic cells in shaping teeth across vertebrates, aiding future dental disorder treatments.
Area of Science:
- Developmental Biology
- Cell Biology
- Evolutionary Biology
Background:
- Tooth germ development requires precise regulation of cell proliferation and programmed cell death.
- Apoptosis, a key form of programmed cell death, is essential throughout embryonic development, including odontogenesis.
- Apoptosis regulates critical stages like tooth initiation, morphogenesis, and signaling center removal.
Purpose of the Study:
- To summarize current knowledge on apoptotic cell distribution and function during odontogenesis in vertebrates.
- To focus on the regulatory roles of apoptosis in cellular processes during tooth development.
- To review apoptosis-associated molecular signaling and its link to autophagy in tooth development.
Main Methods:
- Literature review of recent research on apoptosis in odontogenesis.
- Focus on vertebrate lineages, particularly amniotes (mammals and reptiles).
- Analysis of molecular signaling pathways and autophagic relationships.
Main Results:
- Apoptosis plays diverse roles in tooth germ formation and patterning.
- Apoptosis is linked to specific molecular signaling pathways during tooth development.
- Disruption of apoptotic pathways in transgenic models reveals their importance in dental disorders.
Conclusions:
- Apoptosis is a fundamental process in normal tooth development.
- Understanding apoptosis in odontogenesis offers insights into dental disorders.
- Further research into apoptotic pathways may reveal new therapeutic strategies for dental conditions.
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