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COVID-19 and Cardiomyopathy: A Systematic Review

Fatemeh Omidi1, Bahareh Hajikhani2, Seyyedeh Neda Kazemi3

  • 1Department of Cardiology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Cardiovascular Medicine
|July 5, 2021
PubMed

Insights

Sudden cardiac death in adolescents is often linked to cardiomyopathies (CMPs). This study found cardiac injury and CMPs are common in COVID-19 patients, highlighting the need for cardiac monitoring.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiomyopathies (CMPs) are a significant cause of sudden adolescent death and heart failure.
  • Limited data existed on cardiac complications in COVID-19 patients during the pandemic.
  • Investigating the link between COVID-19 and CMPs is crucial for understanding severe outcomes.

Approach:

  • A systematic literature search was performed across major databases (PubMed/Medline, Web of Science, Embase) up to August 2020.
  • Included 29 articles encompassing 1460 patients diagnosed with COVID-19 and cardiomyopathy.
  • Analyzed comorbidities, laboratory findings, and echocardiographic results.

Key Points:

  • Hypertension, diabetes, obesity, hyperlipidemia, and ischemic heart disease were common comorbidities.
  • Elevated troponin levels were observed in 21.47% of patients.
  • All patients exhibited raised D-dimer levels, and varying degrees of Left Ventricular (LV) dysfunction were noted.

Conclusions:

  • Cardiac injury and CMPs are frequently observed in patients with COVID-19.
  • The findings suggest that cardiac damage should be a key consideration in the management of COVID-19 patients.
  • Further research is warranted to elucidate the mechanisms and long-term implications of COVID-19-associated cardiac complications.

Keywords:
COVID-19SARS-CoV-2cardiac injury and regenerationcardiomyopathysystematic review

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