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Urticarial vasculitis
Stephanie L Gu1, Joseph L Jorizzo1,2
1Department of Dermatology, Weill Cornell Medicine, New York, NY, United States.
International Journal of Women'S Dermatology
|July 5, 2021
Summary
Urticarial vasculitis presents as chronic hives lasting over 24 hours, sometimes indicating underlying conditions. Treatment ranges from antibiotics and dapsone to immunosuppressives and biologics for severe cases.
Area of Science:
- Dermatology
- Pathology
- Immunology
Background:
- Urticarial vasculitis is a rare condition with chronic urticarial lesions.
- Lesions persist for ≥24 hours and may cause hyperpigmentation, distinguishing it from chronic idiopathic urticaria.
- It is often idiopathic but associated with drugs, infections, autoimmune diseases, and malignancies.
Purpose of the Study:
- To review the clinicopathologic features, associations, and therapeutic strategies for urticarial vasculitis.
Main Methods:
- Literature review of urticarial vasculitis, focusing on clinical presentation, histopathology, associations, and treatment outcomes.
- Analysis of diagnostic criteria, including histopathologic findings of leukocytoclastic vasculitis.
- Evaluation of current and emerging therapeutic options.
Main Results:
- Urticarial vasculitis can manifest with systemic involvement affecting multiple organ systems.
- Histopathologic confirmation of leukocytoclastic vasculitis is diagnostic but not always present.
- A spectrum of treatments is employed, from first-line agents like dapsone to advanced therapies.
Conclusions:
- Urticarial vasculitis requires careful diagnosis due to overlapping features with other urticarial conditions.
- Identifying underlying causes is crucial for effective management.
- Treatment approaches are tailored to disease severity, ranging from conventional to biologic therapies for refractory cases.
Keywords:
HypocomplementemicHypocomplementemic urticarial vasculitisLeukocytoclastic vasculitisUrticarial vasculitisUrticarial vasculitis syndromeMore Related Videos
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