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Updated: Aug 6, 2026

Bovine Ovarian Cortex Tissue Culture
Published on: January 14, 2021
Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with
Carrie Riestenberg1, Susan Ahern2, Mousa Shamonki3
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California-Los Angeles, Los Angeles, California.
Objective:
To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2.
Design:
Case report.
Setting:
Private in vitro fertilization clinic.
Patients:
25-Year-old woman, G0, with autoimmune POI and PGAS type 2.
Interventions:
Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation.
Main Outcomes Measures:
Successful stimulation with exogenous gonadotropins, oocyte retrieval, and cryopreservation.
Results:
Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes.
Conclusions:
Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.
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