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3D cell aggregate printing technology and its applications.

Seunggyu Jeon1, Se-Hwan Lee1,2, Saeed B Ahmed2

  • 1School of Life Sciences, Ulsan National Institute of Science and Technology, 50, UNIST-gil, Ulju-gun 44919, Ulsan, South Korea.

Essays in Biochemistry
|July 5, 2021
PubMed
Summary

3D cell aggregate printing offers automated, high-resolution fabrication of complex engineered tissues, overcoming limitations of conventional methods for tissue engineering and drug screening.

Keywords:
3D bioprintingcell aggregatetissue engineeringtissue/disease model

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Conventional cell aggregate culture methods are labor-intensive and limited in creating complex 3D tissues.
  • Three-dimensional (3D) cell aggregate printing technology enables automated fabrication of intricate tissue constructs.

Purpose of the Study:

  • To review the current state and applications of 3D cell aggregate printing technology.
  • To discuss the technical advancements, challenges, and future directions in the field.

Main Methods:

  • Review of recent advancements in 3D cell aggregate printing technologies.
  • Analysis of applications in tissue engineering, disease modeling, and drug screening.

Main Results:

  • 3D cell aggregate printing achieves high resolution (~20 μm) and high speed (milliseconds).
  • Applications include creating engineered tissues, disease models, and drug-screening platforms.

Conclusions:

  • 3D cell aggregate printing is crucial for advanced tissue engineering but faces challenges in mimicking native tissue structure and function.
  • Further development is needed to overcome technical hurdles and realize the full potential of this technology.