Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

47
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
47
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

151
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
151
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

103
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
103
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

85
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
85

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T peripheral helper 1 cells effectively drive atypical double-negative CD11c<sup>hi</sup> B cells to antibody-secreting cells and play a pathogenic role in systemic lupus erythematosus.

Clinical immunology (Orlando, Fla.)·2026
Same author

Sarcoidosis-like reaction associated with tocilizumab in a patient with giant cell arteritis: a case based review.

Rheumatology international·2026
Same author

Correction: Diagnostic and therapeutic challenges in concomitant axial spondyloarthritis and rheumatoid arthritis: a case-based review.

Rheumatology international·2026
Same author

Diagnostic and therapeutic challenges in concomitant axial spondyloarthritis and rheumatoid arthritis: a case-based review.

Rheumatology international·2026
Same author

Real-world effectiveness, safety and patient-reported outcomes of sarilumab in patients with rheumatoid arthritis: a 52-week, prospective, open-label, non-interventional, observational, nationwide, large-cohort study in Japan (PROFILE-J).

RMD open·2026
Same author

Case Report: Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Preceded by Cutaneous Vasculitis: Implications for a Shared Pathogenesis.

International journal of rheumatic diseases·2026

Related Experiment Video

Updated: Oct 30, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.4K

Dropped head in systemic sclerosis: a case based review.

Tatsuya Shimada1,2, Misako Higashida-Konishi1, Mitsuhiro Akiyama3,4

  • 1Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Tokyo, 1528902, Japan.

Rheumatology International
|July 5, 2021
PubMed
Summary

Dropped head syndrome in systemic sclerosis is rare but treatable. Early immunosuppressive therapy can improve symptoms and prevent irreversible damage.

Keywords:
Anti-topoisomerase I antibodyDropped head syndromeInflammatory myopathyMyositisSystemic sclerosis

More Related Videos

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

32.6K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.6K

Related Experiment Videos

Last Updated: Oct 30, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.4K
Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

32.6K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.6K

Area of Science:

  • Rheumatology
  • Neurology
  • Immunology

Background:

  • Dropped head syndrome (DHS) is characterized by severe neck extensor muscle weakness.
  • Systemic sclerosis (SSc) is a rare cause of DHS, with limited understanding of its clinical features and prognosis.
  • This case highlights a treatable neurological manifestation of SSc.

Observation:

  • A patient with SSc presented with severe DHS and mild proximal limb weakness.
  • Elevated creatine kinase, myopathic changes on EMG, and MRI gadolinium enhancement in neck muscles were noted.
  • Positive anti-topoisomerase I antibody confirmed SSc, with negative anti-PM/Scl and anti-Ku antibodies.

Findings:

  • High-dose glucocorticoid therapy led to significant improvement in DHS.
  • Treatment also normalized creatine kinase levels and reduced MRI gadolinium enhancement.
  • Literature review suggests immunosuppressive therapy is effective for DHS in SSc.

Implications:

  • DHS in SSc is a treatable condition requiring early diagnosis and intervention.
  • Prompt treatment can prevent irreversible organ damage and functional decline.
  • Recognizing this rare manifestation is crucial for managing patients with systemic sclerosis.