Hospital admission for symptoms exacerbation in 2,075 infants suffering from recurrent asthma-like symptoms: (EISL-3

Javier Mallol1, Dirceu Solé2, Carolina Aranda2

  • 1Department of Pediatric Respiratory Medicine, Hospital El Pino, University of Santiago de Chile (USACH), Santiago, Chile; javier.mallol@usach.cl.

Insights

Infants with recurrent asthma-like symptoms are frequently hospitalized. Maternal smoking during pregnancy and early wheezing onset increase admission risk, while breastfeeding and higher socioeconomic status offer protection.

Area of Science:

  • Pediatrics
  • Respiratory Medicine
  • Epidemiology

Background:

  • The prevalence and risk factors for infant hospitalization due to asthma/wheezing are not well-understood.
  • This knowledge gap contrasts with existing data for older children and adults.

Purpose of the Study:

  • To determine the prevalence of hospital admissions for wheezing exacerbations in infants with recurrent asthma-like symptoms.
  • To identify factors associated with these hospitalizations.

Main Methods:

  • A cohort of 2,079 infants (12-18 months) with recurrent asthma-like symptoms was studied across 11 South American centers.
  • Data were analyzed using descriptive statistics and multivariate logistic regression.

Main Results:

  • The prevalence of hospital admission for wheezing was 29.7%.
  • Risk factors included severe wheezing episodes, physician-diagnosed asthma, inhaled corticosteroid use, maternal smoking during pregnancy, and early wheezing onset (first trimester).
  • Protective factors included breastfeeding for at least 4 months, higher maternal education, and higher household income.

Conclusions:

  • Infants with recurrent asthma-like symptoms experience high hospitalization rates.
  • Maternal smoking, early-life viral respiratory illness, and disease severity are key risk factors.
  • Preventive strategies should focus on managing exacerbations, promoting breastfeeding, and avoiding smoking during pregnancy.
Abstract

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