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Clinical features of children with atopic dermatitis according to filaggrin gene variants

Ziaali Arghavan1, Sharifi Laleh2, Teimourian Shahram3

  • 1Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Allergologia Et Immunopathologia
|July 5, 2021
PubMed

Insights

Filaggrin gene (FLG) variants were linked to patient age and early-onset atopic dermatitis (AD) in Iranian children. Further research is needed to confirm these findings in a larger population.

Area of Science:

  • Genetics and Dermatology
  • Molecular Biology
  • Epidemiology

Background:

  • Filaggrin (FLG) is crucial for epidermal barrier function.
  • FLG gene mutations are implicated in 50% of atopic dermatitis (AD) cases.
  • Investigating FLG polymorphisms in Iranian children with AD is important.

Purpose of the Study:

  • To investigate filaggrin (FLG) gene polymorphisms and mutations in Iranian children with atopic dermatitis (AD).
  • To explore potential associations between FLG variants and clinical characteristics of AD.

Main Methods:

  • A case-controlled study involving 25 children with AD and 25 healthy controls.
  • Collection of demographic data, clinical manifestations, and FLG single nucleotide polymorphisms (SNPs).
  • Blood samples analyzed for IgE levels and complete blood count.

Main Results:

  • A significant association was found between FLG polymorphism (rs66831674) and patient age.
  • FLG polymorphism (rs41267154) was associated with the early onset of AD.
  • No significant differences in FLG polymorphisms were observed regarding AD severity, ethnicity, concurrent allergies, eosinophilia, or IgE levels.

Conclusions:

  • FLG variants rs66831674 and rs41267154 show associations with age and early-onset AD.
  • Larger-scale studies in the Iranian population are required to validate these findings.
  • Prospective cohort studies are recommended to assess the progression of atopic disorders based on FLG polymorphisms.
Abstract

Keywords:
Iranatopic dermatitisfilaggrinsingle nucleotide polymorphism

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