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Allergic reactions to midazolam: A case series from an Italian allergy unit

Eleonora Nucera1, Giuseppe Parrinello1, Alessandro Buonomo1

  • 1Allergy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Allergologia Et Immunopathologia
|July 5, 2021
PubMed

Insights

Allergic reactions to midazolam, a common sedative, can occur. This study confirms these reactions with positive skin tests in five patients, highlighting a need for awareness.

Area of Science:

  • Pharmacology
  • Allergology
  • Clinical Medicine

Background:

  • Midazolam is a widely used short-acting benzodiazepine for conscious sedation.
  • Adverse reactions to midazolam are documented, but confirmed allergic responses are rare in literature.

Observation:

  • The study presents five distinct clinical cases of allergic reactions attributed to midazolam.
  • These reactions manifested in various ways, indicating a spectrum of hypersensitivity.

Findings:

  • Positive allergological tests, specifically skin tests, were demonstrated in all five cases.
  • This provides objective evidence linking midazolam exposure to allergic responses.

Implications:

  • Clinicians should consider midazolam allergy in patients experiencing adverse reactions.
  • Further investigation into midazolam hypersensitivity mechanisms and diagnostic approaches is warranted.
Keywords:
Kounis syndromeanaphylaxiscase seriesmidazolam hypersensitivityskin tests

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