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Updated: Oct 30, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
A Case of Cyclic Neutropenia and Associated Amyloidosis
Chibuzo Ilonze1,2, Kari M Galipp1, Teresa Scordino3
1Department of Pediatrics, Jimmy Everest Section of Pediatric Hematology/Oncology.
Abstract:
Cyclic neutropenia has been rarely associated with chronic inflammation and development of reactive AA amyloidosis. We report a family with cyclic neutropenia with associated renal and thyroid amyloid. A 12-year-old female presented with thyromegaly, recurrent aphthous ulcers, severe neutropenia, and renal failure. Renal and thyroid biopsies revealed abundant amyloid deposition. Presence of a heterozygous ELANE c.358 A>T gene mutation p.I120F variant with autosomal dominant inheritance confirmed the diagnosis of cyclic neutropenia. The patient's father also had neutropenia and amyloidosis with renal failure. We started filgrastim to attenuate neutropenia and thereby reduce chronic inflammation and minimize further amyloid deposition.
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