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Bruch Membrane Opening Minimum Rim Width in Neuromyelitis Optica.

Lorane Bechet1, Philippe Cabre, Harold Merle

  • 1Departments of Ophthalmology (LB, HM); and Neurology (PC), University Hospital of Martinique, Fort de France, France (French West Indies).

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|July 5, 2021
PubMed
Summary

Bruch membrane opening minimum rim width (BMO) is reduced in neuromyelitis optica (NMO) and multiple sclerosis (MS) patients, correlating with visual function deficits. BMO measurement aids in detecting early optic neuropathy in NMO.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Neuromyelitis optica (NMO) and multiple sclerosis (MS) are demyelinating diseases causing neurodegeneration and optical atrophy.
  • Optical coherence tomography (OCT) quantifies retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness, which correlate with visual function.
  • Evaluating Bruch membrane opening minimum rim width (BMO) offers insights into optic nerve damage in NMO.

Purpose of the Study:

  • To assess Bruch membrane opening minimum rim width (BMO) in patients with NMO using OCT.
  • To compare BMO thickness in NMO, MS, and control groups.
  • To investigate the structure-function relationship between BMO and visual parameters.

Main Methods:

  • OCT was used to measure BMO thickness in 25 NMO patients, 50 MS patients, and 51 controls.
  • Visual functions including visual acuity, contrast sensitivity (Pelli-Robson, Sloan), color vision, and visual field (SAP, FDT) were assessed.
  • Correlations between BMO measurements and visual function tests were analyzed.

Main Results:

  • Average BMO thickness was significantly reduced in NMO and MS patients, irrespective of optic neuritis history.
  • NMO patients without optic neuritis showed significant BMO thinning in average, nasal, and inferonasal sectors.
  • BMO thickness strongly correlated with contrast sensitivity and visual field indices.

Conclusions:

  • BMO thickness decreases following optic neuritis in NMO and MS.
  • BMO is more sensitive than RNFL and GCL in detecting subclinical impairment in NMO patients.
  • BMO measurements correlate well with visual function, highlighting its clinical utility.