Related Experiment Video

Updated: Oct 29, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

328

Prognostic value of C-reactive protein/albumin ratio in hypertensive COVID-19 patients

İbrahim Halil Özdemir1, Bülent Özlek2, Mehmet Burak Özen1

  • 1Department of Cardiology, Manisa City Hospital, Manisa, TURKEY.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|July 6, 2021
PubMed

Insights

The C-reactive protein/albumin ratio (CAR) is a strong predictor of mortality in hypertensive COVID-19 patients. Higher CAR levels indicate a worse prognosis and increased risk of death.

Area of Science:

  • Clinical Medicine
  • Infectious Diseases
  • Cardiology

Background:

  • Hypertension is a common comorbidity in COVID-19 patients.
  • Predictive markers for COVID-19 prognosis are crucial for patient management.

Purpose of the Study:

  • To investigate the prognostic value of the C-reactive protein/albumin ratio (CAR) in hypertensive COVID-19 patients.
  • To determine if CAR can predict mortality in this patient group.

Main Methods:

  • Single-center retrospective study of 281 hypertensive, ICU-admitted COVID-19 patients.
  • Comparison of CAR levels between survivor and non-survivor groups.
  • Logistic regression analysis to evaluate CAR's effect on mortality.

Main Results:

  • CAR was significantly higher in non-survivors (p<0.001).
  • CAR demonstrated an area under the ROC curve of 0.807 for mortality prediction.
  • A CAR cut-off value of 56.62 predicted a 4.9-fold increase in mortality risk.

Conclusions:

  • CAR is a powerful and independent prognostic marker for hypertensive COVID-19 patients.
  • CAR can effectively predict mortality and disease progression.
Abstract

Keywords:
C-reactive proteinCOVID-19albuminc-reactive protein/albumin ratiohypertension

More Related Videos

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

2.4K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.0K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
281
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
160
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
47
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
460
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
539
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
106